Talos: Neutralizing Vulnerabilities with Security Workarounds for Rapid Response

Considerable delays often exist between the discovery of a vulnerability and the issue of a patch. One way to mitigate this window of vulnerability is to use a configuration workaround, which prevents the vulnerable code from being executed at the cost of some lost functionality -- but only if one is available. Since program configurations are not specifically designed to mitigate software vulnerabilities, we find that they only cover 25.2% of vulnerabilities. To minimize patch delay vulnerabilities and address the limitations of configuration workarounds, we propose Security Workarounds for Rapid Response (SWRRs), which are designed to neutralize security vulnerabilities in a timely, secure, and unobtrusive manner. Similar to configuration workarounds, SWRRs neutralize vulnerabilities by preventing vulnerable code from being executed at the cost of some lost functionality. However, the key difference is that SWRRs use existing error-handling code within programs, which enables them to be mechanically inserted with minimal knowledge of the program and minimal developer effort. This allows SWRRs to achieve high coverage while still being fast and easy to deploy. We have designed and implemented Talos, a system that mechanically instruments SWRRs into a given program, and evaluate it on five popular Linux server programs. We run exploits against 11 real-world software vulnerabilities and show that SWRRs neutralize the vulnerabilities in all cases. Quantitative measurements on 320 SWRRs indicate that SWRRs instrumented by Talos can neutralize 75.1% of all potential vulnerabilities and incur a loss of functionality similar to configuration workarounds in 71.3% of those cases. Our overall conclusion is that automatically generated SWRRs can safely mitigate 2.1x more vulnerabilities, while only incurring a loss of functionality comparable to that of traditional configuration workarounds.Comment: Published in Proceedings of the 37th IEEE Symposium on Security and Privacy (Oakland 2016

Transport of non tracer particles in simple flows

Se realizó un estudio experimental del comportamiento de partículas transportadas en un flujo simple. Para ello se utilizaron pares de canales milimétricos con un ángulo de intersección de 0°, y un segmento de comunicación entre ellos, por los cuales se inyectan simultáneamente dos fluidos miscibles. Uno de los fluidos es una solución de agua que contiene un colorante (trazador pasivo) y microesferas (partículas no trazadoras) de flotabilidad neutra, el otro fluido está formado por la misma solución, pero sin ningún tipo de trazador. Para el análisis sistemático de las trayectorias de las partículas, se implementó un dispositivo experimental con técnicas de rastreo de partículas. Los experimentos fueron filmados con alta resolución temporal y espacial utilizando una cámara de alta resolución acoplada a una lupa de laboratorio. Las imágenes se analizaron con un programa de procesamiento desarrollado en el laboratorio. Se analizaron las trayectorias de las partículas para distintos número de Reynolds, obteniéndose la distribución, las velocidades y la concentración de microesferas a la salida de cada canal en función de los parámetros estudiados.An experimental study on the behaviour of transported particles in a flow of simple geometry has been developed. A pair of millimetric channels that cross at 0°, with a shunt between them where two miscible fluids are inyected at constant flow rate. One of the fluids is a solution of dye (passive tracer) as well as microbeads (non passive tracer) of neutral buoyancy. The other fluid is made of the same solution but without any tracer. For the systematic study of the particle trajectories an experimental tracking method has been set up. The experiments have been recorded with a high spatial and temporal resolution camera coupled to a low power microscope. The images have been analysed with a coded processing program developed in our laboratory. The trajectories of the particles, with different Reynolds number, have been analysed, in order to obtain the distribution, speed and bead concentration at each outlet as a function of the used parameters and have been compared with previous results on similar geometries and miscible fluids.Fil: Brabat, M.. École Nationale Supérieure D'électronique, Informatique, Télécommunications, Mathématiques et Mécanique de Bordeaux; FranciaFil: Freytes, Verónica Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: Cachile, Mario Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: D'angelo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentin

Cosiendo los retazos de la economía popular y en el mientrastanto incomodando al sentido común

This article presents the results of a territorial research whose empirical purpose is those areas of the Buenos Aires Conurbano (outer Buenos Aires) where people has been developing land and housing access strategies outside the formal real estate market: villas, settlements and neighborhoods of the state housing and urbanization policy. It began in 2011 and provides weighted primary statistical information on more than 15,000 homes and households and 65,000 people in 14 neighborhoods. This research work is concerned with the study of social reproduction strategies of households in the popular economy, which has required the construction of conceptual categories that enable the dialogue between theory and empire. These categories are sketches or questions in some cases and in others they have already reached a certain degree of maturity, and are the product of the articulation of the individual research lines of the team members, while others are the basis for collective research.Fil: Vio, Marcela. Universidad Nacional de AvellanedaFil: Vio, Marcela. Universidad de Buenos Aires. Facultad de Arquitectura, Diseño y UrbanismoFil: Vio, Marcela. CONICETFil: Cabrera, M. Claudia. Universidad Nacional de AvellanedaFil: Cabrera, M. Claudia. Universidad de Buenos Aires. Facultad de Ciencias SocialesFil: Zucchiatti, Nuria. Universidad Nacional de QuilmesFil: D'Angelo, Analía. Universidad Nacional de Avellaneda - CONICETFil: Martinelli, Viviane. Universidad Nacional de Avellaneda - CONICETFil: Frega, Mariana. Universidad Nacional de Avellaneda - CONICETEste artigo apresenta os resultados duma pesquisa territorial que tem como objeto empírico aqueles territórios do Conurbano Bonaerense nos quais o acesso se dá por fora do mercado imobiliário formal: favelas, assentamentos precários e bairros produto da política pública habitacional e de urbanização. A pesquisa teve início em 2011 e fornece informação estatística primária sobre mais de 15.000 domicílios e unidades domésticas e 65.000 habitantes de 14 bairros. Desenvolve-se o estudo das estratégias de reprodução social das unidades domésticas da economia popular realmente existente, o que tem exigido a construção de categorias conceituais próprias que possibilitem o diálogo entre teoria e objeto empírico. Estas categorias são noções conceituais ou perguntas que, em alguns casos, já alcançaram certo grau de amadurecimento, e são produto da articulação entre as linhas de pesquisa individuais das integrantes do grupo, enquanto outras orientam a pesquisa coletiva.Este artículo presenta resultados de una investigación territorial que tiene por objeto empírico aquellos territorios del Conurbano Bonaerense a los que se accede por fuera del mercado inmobiliario formal: villas, asentamientos y barrios productos de la política estatal de vivienda y urbanización. La misma se inició en 2011 y brinda información primaria estadística ponderada acerca de más de 15.000 viviendas y hogares y 65.000 personas de 14 barrios. Nos ocupa el estudio de las estrategias de reproducción social de los hogares de la economía popular realmente existente, lo que ha demandado la construcción de categorías conceptuales propias que habiliten el dialogo entre teoría y empiria. Estas categorías son esbozos o preguntas en algunos casos y en otros han alcanzado ya cierto grado de maduración, y son el producto de la articulación de las líneas de investigación individuales de las integrantes del equipo, mientras que otras vertebran la investigación colectiva

Experimental study of the buckling of a semi-flexible filament in a complex medium

En este trabajo se estudia la deformación por compresión de un filamento delgado inmerso en un fluido.Se estudia la forma del filamento variando la magnitud de la compresión aplicada y las propiedades reológicas del medio: puramente viscoso, puramente elástico y con comportamiento viscoelástico.Se observan transiciones entre regímenes de diferente estabilidad.In this work we study the deformation of a thin filament immersed in different fluids when subjected to a compressive force. The filament shape is analyzed for different magnitudes of the applied compression and for different rheological properties of the medium: purely viscous, purely elastic and displaying viscoelastic behavior. Transitions between different regimes are observed.Fil: Van Der Velde, Guido Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Gómez, C.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Freytes, Verónica Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: Bruno, L.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: D'angelo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentin

Cosiendo los retazos de la economía popular y en el mientrastanto incomodando al sentido común

Este artículo presenta resultados de una investigación territorial que tiene por objeto empírico aquellos territorios del Conurbano bonaerense a los que se accede por fuera del mercado inmobiliario formal: villas, asentamientos y barrios productos de la política estatal de vivienda y urbanización. La misma se inició en 2011, y brinda información primaria estadística ponderada acerca de más de 15.000 viviendas y hogares y 65.000 personas de 14 barrios. Nos ocupa el estudio de las estrategias de reproducción social de los hogares de la economía popular realmente existente, lo que ha demandado la construcción de categorías conceptuales propias que habiliten el dialogo entre teoría y empiria. Estas categorías son esbozos o preguntas en algunos casos y en otros han alcanzado ya cierto grado de maduración, y son el producto de la articulación de las líneas de investigación individuales de las integrantes del equipo, mientras que otras vertebran la investigación colectiva.This article presents the results of a territorial research whose empirical purpose is those areas of the Buenos Aires Conurbano (outer Buenos Aires) where people has been developing land and housing access strategies outside the formal real estate market:villas, settlements and neighborhoods of the state housing and urbanization policy. It began in 2011 and provides weighted primary statistical information on more than 15,000 homes and households and 65,000 people in 14 neighborhoods. This research work is concerned with the study of social reproduction strategies of households in the popular economy, which has required the construction of conceptual categories that enable the dialogue between theory and empire. These categories are sketches or questions in some cases and in others they have already reached a certain degree of maturity, and are the product of the articulation of the individual research lines of the team members, while others are the basis for collective research.Fil: Vio, Marcela Laura. Universidad Nacional de Avellaneda; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cabrera, Maria Claudia. Universidad Nacional de Avellaneda; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Carrera de Sociología; ArgentinaFil: Zucchiatti, Nuria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Avellaneda; ArgentinaFil: D'angelo, Analía Soledad. Universidad Nacional de Avellaneda; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinelli de Almeida, Viviane. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Avellaneda; ArgentinaFil: Frega, Mariana Gabriela. Universidad Nacional de Avellaneda; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview

Journal pre-proofsCurcumin (CUR) is a phenolic compound present in some herbs, including Curcuma longa Linn. (turmeric rhizome), with a high bioactive capacity and characteristic yellow color. It is mainly used as a spice, although it has been found that CUR has interesting pharmaceutical properties, acting as a natural antioxidant, anti-inflammatory, antimicrobial, and antitumoral agent. Nonetheless, CUR is a hydrophobic compound with low water solubility, poor chemical stability, and fast metabolism, limiting its use as a pharmacological compound. Smart drug delivery systems (DDS) have been used to overcome its low bioavailability and improve its stability. The current work overviews the literature from the past 10 years on the encapsulation of CUR in nanostructured systems, such as micelles, liposomes, niosomes, nanoemulsions, hydrogels, and nanocomplexes, emphasizing its use and ability in cancer therapy. The studies highlighted in this review have shown that these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged CUR release, and reduced side effects, among other interesting advantages.This study was funded by the Coordination for Higher Level Graduate Improvements (CAPES/Brazil, finance code 001), National Council for Scientific and Technological Development (CNPq/Brazil, PIBIC process #123483/2020-4), State of São Paulo Research Foundation (FAPESP/Brazil, processes #2017/10789-1, #2018/10799-0, #2018/06475-4, #2018/07707-6, #2019/08549-8, and #2020/03727-2). This work was also supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and the project AgriFood XXI (NORTE-01-0145-FEDER-000041) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. Our Figures were created with BioRenderinfo:eu-repo/semantics/publishedVersio

ESHRE guideline: female fertility preservation.

Study questionWhat is the recommended management for women and transgender men with regards to fertility preservation (FP), based on the best available evidence in the literature?Summary answerThe ESHRE Guideline on Female Fertility Preservation makes 78 recommendations on organization of care, information provision and support, pre-FP assessment, FP interventions and after treatment care. Ongoing developments in FP are also discussed.What is known alreadyThe field of FP has grown hugely in the last two decades, driven by the increasing recognition of the importance of potential loss of fertility as a significant effect of the treatment of cancer and other serious diseases, and the development of the enabling technologies of oocyte vitrification and ovarian tissue cryopreservation (OTC) for subsequent autografting. This has led to the widespread, though uneven, provision of FP for young women.Study design size durationThe guideline was developed according to the structured methodology for development of ESHRE guidelines. After formulation of key questions by a group of experts, literature searches and assessments were performed. Papers published up to 1 November 2019 and written in English were included in the review.Participants/materials setting methodsBased on the collected evidence, recommendations were formulated and discussed until consensus was reached within the guideline group. A stakeholder review was organized after finalization of the draft. The final version was approved by the guideline group and the ESHRE Executive Committee.Main results and the role of chanceThis guideline aims to help providers meet a growing demand for FP options by diverse groups of patients, including those diagnosed with cancer undergoing gonadotoxic treatments, with benign diseases undergoing gonadotoxic treatments or those with a genetic condition predisposing to premature ovarian insufficiency, transgender men (assigned female at birth), and women requesting oocyte cryopreservation for age-related fertility loss.The guideline makes 78 recommendations on information provision and support, pre-FP assessment, FP interventions and after treatment care, including 50 evidence-based recommendations-of which 31 were formulated as strong recommendations and 19 as weak-25 good practice points and 3 research only recommendations. Of the evidence-based recommendations, 1 was supported by high-quality evidence, 3 by moderate-quality evidence, 17 by low-quality evidence and 29 by very low-quality evidence. To support future research in the field of female FP, a list of research recommendations is provided.Limitations reasons for cautionMost interventions included are not well studied in FP patients. As some interventions, e.g. oocyte and embryo cryopreservation, are well established for treatment of infertility, technical aspects, feasibility and outcomes can be extrapolated. For other interventions, such as OTC and IVM, more evidence is required, specifically pregnancy outcomes after applying these techniques for FP patients. Such future studies may require the current recommendations to be revised.Wider implications of the findingsThe guideline provides clinicians with clear advice on best practice in female FP, based on the best evidence currently available. In addition, a list of research recommendations is provided to stimulate further studies in FP.Study funding/competing interestsThe guideline was developed and funded by ESHRE, covering expenses associated with the guideline meetings, with the literature searches and with the dissemination of the guideline. The guideline group members did not receive payment. R.A.A. reports personal fees and non-financial support from Roche Diagnostics, personal fees from Ferring Pharmaceuticals, IBSA and Merck Serono, outside the submitted work; D.B. reports grants from Merck Serono and Goodlife, outside the submitted work; I.D. reports consulting fees from Roche and speaker's fees from Novartis; M.L. reports personal fees from Roche, Novartis, Pfizer, Lilly, Takeda, and Theramex, outside the submitted work. The other authors have no conflicts of interest to declare.DisclaimerThis guideline represents the views of ESHRE, which were achieved after careful consideration of the scientific evidence available at the time of preparation. In the absence of scientific evidence on certain aspects, a consensus between the relevant ESHRE stakeholders has been obtained. Adherence to these clinical practice guidelines does not guarantee a successful or specific outcome, nor does it establish a standard of care. Clinical practice guidelines do not replace the need for application of clinical judgment to each individual presentation, nor variations based on locality and facility type. ESHRE makes no warranty, express or implied, regarding the clinical practice guidelines and specifically excludes any warranties of merchantability and fitness for a particular use or purpose. (Full disclaimer available at  www.eshre.eu/guidelines.) †ESHRE Pages content is not externally peer reviewed. The manuscript has been approved by the Executive Committee of ESHRE

Memorias de crónicas de El Bolsón : La Feria Regional, historias y personajes

Por la experiencia personal del trabajo atípico, se eligió retratar el submundo de los artesanos y productores de la Feria Regional de El Bolsón. La idea de contar las historias de vida y anécdotas de diferentes personajes de un pueblo patagónico tiene como objetivo interesar a los lectores acerca de las posibilidades de desarrollar un emprendimiento autónomo y sostenible mediante la producción manual tanto de objetos como de alimentos. La crónica como género periodístico permite una mayor aproximación al terreno y una profundización en las realidades cotidianas de un universo no tan lejano.Facultad de Periodismo y Comunicación Socia

Correlating Sensitive Behaviours with User Interaction on Android

In recent years, ransomware and private information leakage have become more prevalent on mobile devices. Distinguishing such applications from benign ones that make use of similar functionality is challenging because they make use of the exact same APIs. In order to disambiguate these uses, a security analyst may wish to consider whether the user was aware of and consented to the sensitive behaviour. This thesis seeks to aid an analyst making this determination by correlating sensitive behaviours with user interaction. In order to assess user awareness, an analyst should consider all paths to a sensitive behaviour. A path to a sensitive behaviour should be preceded by some UI interaction or a read from persistent storage written to as a consequence of UI interaction. A technique capable of correlating sensitive behaviours with preceding UI interaction has been implemented and evaluated on a suite of synthetic applications.M.A.S

Study of wettability and characterization of the pdms - glass system in microfluidic devices

Se estudió la mojabilidad de superficies de polidimetilsiloxano (PDMS) tratadas con plasma de aire. El PDMS es un elastómero de silicona atractivo como material de base para aplicaciones biomédicas de microfluidos, sin embargo en muchos casos la superficie hidrófoba del PDMS puede ser problemática. El tratamiento  de la superficie con plasma de aire es uno de los métodos convencionales tanto para el sellado de los canales con vidrio, como para la activación de la superficie mejorando las condiciones de hidrofobicidad. En este trabajo la mojabilidad de los PDMS modificados se cuantificó mediante mediciones del ángulo de contacto, para aceite mineral y para agua, depositados sobre superficies de PDMS tratadas.  Se analizó la variación del  ángulo de contacto con el tiempo de exposición al plasma. Se estudió la estabilidad  de las propiedades de mojado en el tiempo posterior al tratado de la superficie. Finalmente se estudió la movilidad de los fluidos de interés (aceite mineral y agua) en los canales de PDMS sellados con vidrio, estudiando la relación Caudal vs. Presión de inyección y comparando las superficies tratadas con aquellas que no fueron expuestas al plasma de aire.Fil: Luengo, Josefina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: Minazzoli, C. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: D'angelo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: Cachile, Mario Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: Freytes, Verónica Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentin